Publikationen 2005 und früher

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Pott C, Schrader C, Brüggemann M, Ritgen M, Harder L, Raff T, Tiemann M, Dreger P, Kneba M: Blastoid variant of mantle cell lymphoma: late progression from classical mantle cell lymphoma and quantitation of minimal residual disease. Eur J Haematol 74:353-358 (2005).

Karpas A, Harder L, Czepulkowski B, Bloxham D, Dremucheva A, Siebert R: Studies of four new human myeloma cell lines. Leukemia Lymphoma 46:101-112 (2005).

Beck C, Humpe A, Harder S, Schmid M, Horst HA: Myelodysplastic syndrome of donor origin subsequent to successful treatment of myeloid/NK-cell precursor leukaemia with allogeneic PBSCT: two very rare conditions in one patient. Ann Hematol 84:616-618 (2005).

Frohling S, Schlenk RF, Krauter J, Thiede C, Ehninger G, Haase D, Harder L, Kreitmeier S, Scholl C, Caligiuri MA, Bloomfield CD, Dohner H, Dohner K: Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations. Genes Chromosomes Cancer 42:427-432 (2005).

Fu K, Weisenburger DD, Greiner TC, Dave S, Wright G, Rosenwald A, Chiorazzi M, Iqbal J, Gesk S, Siebert R, de Jong D, Jaffe ES, Wilson WH, Delabie J, Ott G, Dave BJ, Sanger WG, Smith LM, Braziel RM, Müller-Hermelink HK, Campo E, Gascoyne RD, Staudt LM, Chan WC: Cyclin D1-negative mantle cell lymphoma: a clinicopathological study based on gene expression profiling. Blood 106:4315-4321 (2005).

Gesk S, Gascoyne RD, Schnitzer B, Bakshi N, Janssen D, Klapper W, Martin-Subero JI, Parwaresch R, Siebert R: ALK-positive diffuse large B-cell lymphoma with ALK-Clathrin fusion belongs to the spectrum of pediatric lymphomas. Leukemia 19:1839-1840 (2005).

Marafioti T, Pozzobon M, Hansmann ML, Ventura R, Pileri SA, Roberton H, Gesk S, Gaulard P, Barth TFE, Du MQ, Leoncini L, Möller P, Natkunam Y, Siebert R, Mason DY: The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomas. Br J Haematol 128:333-342 (2005).

Rubio-Moscardo F, Blesa D, Mestre C, Siebert R, Balasas T, Benito A, Rosenwald A, Climent J, Martinez JI, Schilhabel M, Karran EL, Gesk S, Esteller M, deLeeuw R, Staudt LM, Fernandez-Luna JL, Pinkel D, Dyer MJ, Martinez-Climent JA: Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes. Blood 106:3214-3222 (2005).

Ye H, Gong L, Liu H, Hamoudi RA, Shirali S, Ho L, Chott A, Streubel B, Siebert R, Gesk S, Martin-Subero JI, Radford JA, Banerjee S, Nicholson AG, Ranaldi R, Remstein ED, Gao Z, Zheng J, Isaacson PG, Dogan A, Du MQ: MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression. J Pathol 205:293-301 (2005).

Metzke-Heidemann S, Kirsch E, Jordan S, Crohns C, Siebert R, Maass N, Grote W, Gerber W, Schreer, I, Schmutzler R, Arnold N und Jonat W,: Beratung, genetische Diagnostik und Betreuung von Familien mit Veranlagung für Mamma-/Ovarialkarzinome. Schleswig-Holsteinisches Ärzteblatt 9: 51-56 (2005).

Claviez A, Ngoumou B, Harder L, Baumann I, Niemeyer C: Marked thrombocytosis in a child with advanced myelodysplastic syndrome. Leukemia Lymphoma. 45:849-50 (2004).

Kim SZ, Chow KU, Kukoc-Zivojnov N, Boehrer S, Bringer A, Sreimle-Grauer SA, Harder L, Hoelzer D, Mitrou PS, Weidmann E: Expression of ZAP-70 protein correlates with disease stage in chronic lymphocytic leukemia and is associated with, but not generally restricted to, non-mutated Ig VH status. Leukemia Lymphoma 45:2037-45 (2004).

Klein F, Feldhahn N, Harder L, Wang H, Wartenberg M, Hofmann WK, Wernet P, Siebert R, Müschen M: The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells. J Exp Med 199:673-685 (2004).

Saez B, Martin-Subero JI, Guillen-Grima F, Odero MD, Prosper F, Cigudosa JC, Harder L, Calasanz MJ, Siebert R: Chromosomal abnormalities clustering in multiple myeloma reveals cytogenetic subgroups with nonrandom acquisition of chromosomal changes. Leukemia 18:654-657 (2004).

Wilda M, Bruch J, Harder L, Rawer D, Reiter A, Borkhardt A, Woessmann W: Inactivation of the ARF-MDM-2-p53 pathway in sporadic Burkitt’s lymphoma in children. Leukemia 18:584-8 (2004).

Metzke-Heidemann S, Kühling-von Kaisenberg H, Caliebe A, Janssen D, Jonat W, Grote W, von Kaisenberg CS. Phenotypical variation in cousins with the identical partial trisomy 9 (pter-q22.2) and 7 (q35-qter) at 16 and 23 weeks gestation. Am J Med Genet;126(A)2:197-203 (2004).

Hallermann C, Kaune KM, Gesk S, Martin-Subero JI, Gunawan B, Griesinger F, Vermeer MH, Willemze R, Siebert R, Neumann C: Molecular cytogenetic analysis of chromosomal breakpoints in the IGH, MYC, BCL6 and MALT1 gene loci in primary cutaneous B-cell lymphomas. J Invest Dermatol 123: 213-219 (2004).

Kluwe L, Siebert R, Gesk S, Friedrich RE, Tinschert S, Kehrer-Sawatzki H, Mautner VF: Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene. Hum Mutat 23:111-116 (2004).

Sarafidou T, Kahl C, Martinez-Garay I, Mangelsdorf M, Gesk S, Baker E, Kokkinaki M, Talley P, Maltby EL, French L, Harder L, Hinzmann B, Nobile C, Richkind K, Finnis M, Deloukas P, Sutherland GR, Kutche K, Moschonas NK, Siebert R, Gecz J, European Collaborative Consortium for the study of ADLTE: Folate-sensitive fragile site FRA10A is due to an expansion of a CGG-repeat in a novel gene FRA10AC1, encoding a nuclear protein. Genomics 84: 69-81 (2004).

Subklewe M, Nagy M, Schoch C, Jenisch S, Siebert R, Gesk S, Neuhaus P, Dörken B: Extramedullary manifestation of a donor-derived acute myeloid leukemia in a liver transplant patient. Leukemia 18:2050-2053 (2004).

Assaf C, Hummel M, Dippel E, Schwartz S, Geilen CC, Harder L, Siebert R, Steinhoff M, Klemke CD, Thiel E, Goerdt S, Stein H, Orfanos CE: Common clonal T-cell origin in a patient with T-prolymphocytic leukaemia and associated cutaneous T-cell lymphomas. Brit J Haematol, 120:488-491 (2003).

Joos S, Granzow M, Holtgreve-Grez H, Siebert R, Harder L, Martín-Subero JI, Wolf J, Barth TFE, Lichter P, Jauch A: Hodgkin lymphoma cell lines are characterized by frequent aberrations on chromosome 2p and 9p including REL and JAK2. Int J Cancer 103:489-495 (2003).

Gesk S, Martin-Subero JI, Harder L, Luhmann B, Schlegelberger B, Calasanz MJ, Grote W, Siebert R: Molecular cytogenetic detection of chromosomal breakpoints in T-cell receptor loci. Leukemia 17:738-745 (2003).

Harder L, Gesk S, Martin-Subero JI, Merz H, Hochhaus A, Maaß E, Feller A, Grote W, Siebert R, Fetscher S: Cytogenetic and molecular characterization of simultaneous chronic and acute myeloid leukemia. Cancer Genet Cytogen 142:80-82 (2003).

Horsman D, Okamoto I, Ludkovski O, Le N, Harder L, Gesk S, Siebert R, Chanabhai M, Sehn L, Connors J, Gascoyne R: Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two diseases. Brit J Haem 120:424-433 (2003).

Martin-Subero JI, Knippschild U, Harder L, Barth TF, Riemke J, Grohmann S, Gesk S, Höppner J, Möller P, Parwaresch RM, Siebert R: Segmental chromosomal aberrations and centrosome amplifications: pathogenetic mechanisms in Hodgkin and Reed-Sternberg cells of classical Hodgkin’s lymphoma? Leukemia 17:2214-9 (2003).

Steinemann D, Gesk S, Zhang Y, Harder L, Pilarsky C, Hinzmann B, Martin-Subero JI, Calasanz MJ, Mungall A, Rosenthal A, Siebert R, Schlegelberger B: Identification of candidate tumor suppressor genes in 6q27 by combined deletion mapping and electronic expression profiling in lymphoid neoplasms. Gene Chromosome Canc 37:421-426 (2003).

Weng L, Gesk S, Martín-Subero JI, Harder L, Schlegelberger B, Grote W, Dyer MJS, Siebert R: Interphase cytogenetic characterization of aberrations in the long arm of chromosome 1 in B-cell lymphoid malignancies. Cancer Genet Cytogen 144:83-84 (2003).

Martin-Subero JI, Gesk S, Harder L, Grote W, Siebert R: Interphase Cytogenetics of Hematological Neoplasms under the perspective of the perspective of the novel WHO classification. Anticancer Research 23:1139-1148 (2003).

Merz H, Lange K, Gaiser T, Müller A, Kapp U, Bittner C, Harder S, Siebert R, Bentz M, Binder T, Diehl V Feller AC: Characterization of a novel human anaplastic large cell lymphoma cell line tumorigenic in SCID mice. Leukemia Lymphoma 43:165-172 (2002).

Harder L: Bedeutung der genetischen Diagnostik für die Klassifikation und Risikostratifizierung maligner Lymphome. Medizinische Genetik 2-14:115-118 (2002).

Joos S, Menz CK, Wrobel G, Siebert R, Gesk S, Ohl S, Mechtersheimer G, Trümper L, Möller P, Lichter P, Barth TFE: Classical Hodgkin’s lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2. Blood 99:1381-1387 (2002).

Küppers R, Sonoki T, Satterwhite E, Gesk S, Harder L, Oscier DG, Tucker PW, Dyer MJS, Siebert R: Lack of somatic hypermutation of IG V(H) genes in lymphoid malignancies with t(2;14)(p13;q32) translocation involving the BCL11A gene. Leukemia. 16:937-939 (2002).

Martín-Subero JI, Chudoba I, Harder L, Gesk S, Novo FJ, Calasanz MJ, Grote W, Siebert R: Multicolor-Fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms: expanding the possibilities of combined morphologic, immunophenotypic and genetic single cell analyses. Am J Pathol 161:413-420 (2002).

Martín-Subero JI, Gesk S, Harder L, Sonoki T, Tucker PW, Schlegelberger B, Grote W, Novo FJ, Calasanz MJ, Hansmann ML, Dyer MJS, Siebert R: Recurrent involvement of the REL and BCL11A loci in classical Hodgkin’s lymphoma. Blood 99:1474-1477 (2002).

Martín-Subero JI, Harder L, Gesk S, Schlegelberger B, Grote W, Martinez-Climent JA, Dyer MJS, Novo FJ, Calasanz MJ, Siebert R: Interphase FISH assays for the detection of translocations with breakpoints in immunoglobulin light chain loci. Int J Cancer 98:470-474 (2002).

Montesinos-Rongen Manuel, Zühlke-Jenisch R, Gesk S, Martín-Subero JI, Schaller C, Van Roost D, Wiestler OD, Deckert M, Siebert R: Interphase cytogenetic analysis of lymphoma-associated chromosomal breakpoints in primary diffuse large B-cell lymphomas of the central nervous system. J Neuropathol Exp Neur 61:926-933 (2002).

Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S, Saenz A, Poza JJ, Galan J, Gesk S, Sarafidou T, Mautner VF, Binelli S, Staub E, Hinzmann B, French L, Prud’homme JF, Passarelli D, Scannapieco P, Tassinari CA, Avanzini G, Marti-Masso JF, Kluwe L, Deloukas P, Moschonas NK, Michelucci R, Siebert R, Nobile C, Perez-Tur J, Lopez de Munain A: Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Hum Mol Genet 11:1119-1128 (2002).

Nobile C, Hinzmann B, Scannapieco P, Siebert R, Zimbello R, Perez-Tur J, Sarafidou T, Moschonas NK, French L, Deloukas P, Ciccodicola A, Gesk S, Poza JJ, Lo Nigro C, Seri M, Schlegelberger B, Rosenthal A, Valle G, Lopez de Munain A, Tassinari CA, Michelucci R: Identification and characterization of a novel human brain-specific gene, homologous to S. scrofa tmp83.5, in the chromosome 10q24 critical region for temporal lobe epilepsy and spastic paraplegia. Gene 282:87-94 (2002).

Viardot A, Möller P, Högel J, Werner K, Mechtersheimer G, Ho AD, Ott G, Barth TFE, Siebert R, Gesk S, Schlegelberger B, Döhner H, Bentz M: Clinicopathological correlations of genomic gains and losses in follicular lymphoma. J Clin Oncol 20:4523-4530 (2002).

Schlegelberger B, Gesk S, Zhang Y, Siebert R: Simultaneous fluorescence immunophenotyping and FISH (FICTION). In: Rautenstrauß BW, Liehr T (eds), FISH Technology. Springer-Verlag, pp. 442-460 (2002).

Stumm M, von Ruskowsky A, Siebert R, Harder S, Varon R, Wieacker P, Schlegelberger B: No evidence for deletions of the NBS1 gene in lymphomas. Cancer Genet Cytogen 126:60-62 (2001).

Weidmann E, Boehrer S, Chow KU, Engels K, Harder L, Hinz T, Janssen O, Kriener S, Rummel MJ, Siebert R, Kabelitz D, Hansmann ML, Hoelzer D, Mitrou PS for the ‚Study Group Peripheral T- and NK-cell neoplasias‘:Treatment of aggressive or progressing indolent peripheral T- and NK-cell neoplasias by combination of fluodarabine, cyclophosphamide and doxorubicine. Onkologie 24:162-164 (2001).

Harder L, Siebert R, Schlegelberger B: Zytogenetische Untersuchungen bei malignen Lymphomen. In: Mitrou PS (ed), Non-Hodgkin-Lymphome. Buchreihe des Tumorzentrums Rhein-Main (2001).

Boehrer S, Hinz T, Schui D, Harder L, Chow KU, Schneider B, Hoelzer D, Mitrou PS, Weidmann E: T-large granular lymphocyte leukaemia with natural killer cell-like cytotoxicity and expression of two different alpha- and beta-T-cell receptor chains. Br J Haematol 112:201-203 (2001).

Kahl C, Gesk S, Harder L, Harbott J, French L, Deloukas P, Grote W, Schlegelberger B, Siebert R: Detection of translocations involving the HOX11/TCL3-Locus in 10q24 by interphase-FISH. Cancer Genet Cytogen 129:80-84 (2001).

Martín-Subero JI, Harder L, Gesk S, Schoch R, Novo FJ, Grote W, Calasanz MJ, Schlegelberger B, Siebert R: Amplification of ERBB2, RAR and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia. Cancer Genet Cytogen 127:174-176 (2001).

Martín-Subero JI, Siebert R, Harder L, Gesk S, Schwindt P, Bräuninger A, Willenbrock K, Steinemann D, Tiemann M, Calasanz MJ, Grote W, Ludwig WD, Hansmann ML, Schlegelberger B: Cytogenetic and molecular characterization of a patient with simultaneous B-cell chronic lymphocytic leukemia and peripheral T-cell lymphoma. Am J Hemat 68:276-279 (2001).

Metzke-Heidemann S, Harder L, Gesk S, Schoch R, Jenisch S, Grote W, Siebert R, Schlegelberger B: Integration of amplified BCR/ABL fusion genes into the short arm of chromosome 17 as a novel mechanism of disease progression in chronic myeloid leukemia. Gene Chromosome Canc 31:10-14 (2001).

Sanchez-Izquierdo D, Siebert R, Harder L, Marugan I, Gozzetti A, Price HP, Gesk S, Hernandez-Rivas JM, Benet I, Solé F, Sonoki T, Le Beau MM, Schlegelberger B, Dyer MJS, Garcia-Conde J, Martinez-Climent JA: Detection of translocations affecting the BCL6 locus in B-cell non-Hodgkin’s lymphoma by interphase fluorescence in situ hybridization. Leukemia 15:1475-1484 (2001).

Satterwhite E, Sonoki T, Willis TG, Harder L, Nowak R, Arriola EL, Liu H, Price HP, Gesk S, Steinemann D, Schlegelberger B, Oscier DG, Siebert R, Tucker PW, Dyer MJS: The BCL11 gene family: involvement of BCL11A in lymphoid malignancies. Blood 98:3413-3420 (2001).

Sonoki T, Harder L , Horsman DE, Karran EL, Taniguchi I, Willis TG, Gesk S, Steinemann D, Zucca E, Schlegelberger B, Solé F, Mungall AJ, Gascoyne RD, Siebert R, Dyer MJS: Cyclin D3 (CCND3) is a target gene of t(6;14)(p21.1;q32.3) of mature B-cell malignancies. Blood 98:2837-2844 (2001).

Steinemann D, Siebert R, Harder S, Martin-Subero I, Kettwig G, Hinzmann B, Gesk S, Tiemann, M, Merz H, Rosenthal A, Grote W, Morris SW, Schlegelberger B: Frequent allelic loss of the BCL10 gene in lymphomas with the t(11;14)(q13;q32). Leukemia 15:474-477 (2001).

Viardot A, Martin-Subero JI, Siebert R, Harder S, Gesk S, Bentz M, Schlegelberger B: Detection of secondary genetic aberrations in follicle center cell derived lymphomas: assessment of the reliability of comparative genomic hybridization and standard chromosome analysis. Leukemia 15:177-183 (2001).

Bohlander SK, Muschinsky V, Schrader K, Siebert R, Schlegelberger B, Harder L, Schemmel V, Fonatsch C, Ludwig WD, Hiddemann W, Dreyling MH: Molecular analysis of the CALM/AF10 fusion: Identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. Leukemia 14:93-99 (2000).

Zhang Y, Matthiesen P, Harder S, Siebert R, Castoldi G, Calasanz MJ, Wong KF, Rosenwald A, Ott G, Atkin NB, Schlegelberger B: A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridization. Gene Chromosome Canc 27:52-58 (2000).

Zhang Y, Siebert R, Matthiesen P, Harder S, Theile M, Scherneck S, Schlegelberger B: Feasibility of simultaneous fluorescence immunophenotyping and fluorescence in situ hybridization study for the detection of estrogen receptor expression and deletions of the estrogen receptor gene in breast carcinoma cell lines. Virchows Arch 436:271-275 (2000).

Gesk S, Siebert R, Wacker HH, Nürnberg N, Harder L, Lehmann J, Klöppel G, Grote W, Stöckle M, Schlegelberger B: Lack of deletions of the PTEN/MMAC1 and MXI1 loci in renal cell carcinoma by interphase cytogenetics. Cancer Genet Cytogen 118:87-88 (2000).

Ma Z, Cools J, Marynen P, Cui X, Siebert R, Gesk S, Schlegelberger B, Peeters B, De Wolf-Peeters C, Wlodarska I, Morris SW: Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis. Blood 95:2144-2149 (2000).

Schlegelberger B, Zwingers T, Harder L, Nowotny H, Siebert R, Vesely M, Bartels H, Sonnen R, Hopfinger G, Nader A, Ott G, Müller-Hermelink K, Feller A, Heinz R for the Kiel-Wien-Lymphoma Study-Group: Clinicopathogenetic significance of chromosomal abnormalities in patients with blastic peripheral B-cell lymphoma. Blood 94:3114-3120 (1999).

Zhang Y, Wong KF, Siebert R, Matthiesen P, Harder S, Eimermacher H, Feller AC, Schlegelberger B: Chromosome aberrations are restricted to the CD56+ CD3- tumour cell population in natural killer cell lymphomas: A combined immunphenotyping and FISH study. Brit J Haematol 105:737-742 (1999).

Schlegelberger B, Metzke S, Harder S, Zühlke-Jenisch R, Zhang Y, Siebert R: Classical and molecular cytogenetics of tumor cells. In: Wegner RD (ed), Diagnostic Cytogenetics. Springer-Verlag, Berlin, Heidelberg, pp. 151-185 (1999).

Scheurlen WG, Schwabe GC, Seranski P, Joos S, Harbott J, Metzke S, Döhner H, Poustka A, Wilgenbus K, Haas OA: Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q). Genes Chromos Cancer; 25:230-240 (1999).

Siebert R, Gesk S, Harder L, Steinemann D, Wlodarska I, Tiemann M, Schemmel V, Grote W, Schlegelberger B: Complex variant translocation t(1;2) with TPM3-ALK fusion due to cryptic ALK gene rearrangement in anaplastic large cell lymphoma. Blood 94:3614-3617 (1999).

Siebert R, Gesk S, Harder S, Plötz S, Matthiesen P, Grote W, Schlegelberger B, Jandrig B, Grasmo-Wendler UH, Scherneck S, Rosenwald A, Ott G: Deletions in the long arm of chromosome 10 in lymphomas with t(14;18): A pathogenetic role of the tumor suppressor genes PTEN/MMAC1 and MXI1? Blood 92:4487-4489 (1998).

Siebert R, Matthiesen P, Harder S, Zhang Y, Borowski A, Zühlke-Jenisch R, Metzke S, Joos S, Weber-Matthiesen K, Grote W, Schlegelberger B: Application of interphase fluorescence in situ hybridization for the detection of the Burkitt translocation t(8;14)(q24;q32) in B-cell lymphomas. Blood 91:984-990 (1998).

Siebert R, Matthiesen P, Harder S, Zhang Y, Borowski A, Zühlke-Jenisch R, Plendl H, Metzke S, Joos S, Zucca E, Weber-Matthiesen K, Roggero E, Grote W, Schlegelberger B: Application of interphase cytogenetics for the detection of t(11;14)(q13;q32) in mantle cell lymphomas. Ann Oncol 9:519-526 (1998).

Harder S, Siebert R, Grote W, Schlegelberger B: Bedeutung genetischer Aberrationen für die histopathologische und klinisch-prognostische Klassifikation maligner Lymphome. Med Genet 10:307-309 (1998).

Zhang Y, Matthiesen P, Siebert R, Harder S, Theile M, Scherneck S, Schlegelberger B: Detection of 6q deletions in breast carcinoma cell lines by fluorescence in situ hybridization. Hum Genet 103:727-729 (1998).

Metzke H unter Mitarbeit von Metzke S: Lexikon der historischen Krankheitsbezeichnungen. Degener Verlag & Co, D-91413 Neustadt/Aisch (1995).

Metzke S: A Simple Method for „Rescuing“ Clotted Bone Marrow Samples for Cytogenetic Investigations. Leukemia 9:1413-1414 (1995).

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